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Opioid activity is because of both equally very low affinity binding on the father or mother compound and better affinity binding from the O-demethylated metabolite M1 to µ-opioid receptors. In animal products, M1 is approximately six occasions far more powerful than tramadol in producing analgesia and two hundred periods much more strong in µ-op

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Diazepam passes into breast milk. Breastfeeding is as a result not encouraged in patients getting Bensedin.Diazepam and its metabolites are remarkably sure to plasma proteins (diazepam ninety eight%). Diazepam and its metabolites cross the blood-Mind and placental obstacles and also are found in breast milk in concentrations close to a person tenth

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